SuperSol 1000+

Determination of thermodynamic solubilities

FEATURES

• Principle of measurement consistent  with thermodynamic definition
• Replacement of  the shake-flask method
• Continuous monitoring of the dissolution process
• Low consumption of substance (a few mg)
• Flexible choice of media (water, pH Buffer, SIF etc.)
• Simple handling and cleaning
• High dynamic range
• Comprehensive documentation of the results in a report

Overview

The reliable determination of the solubility of drug candidates is of increasing concern in many stages of drug development. The shake-flask method is still a standard even so it has some disadvantages: i) it is labor-intensive and time-consuming, ii) the number of samples to be analyzed within one dissolution measurement is limited, iii) sample taking for the analysis itself imposes additional sources of errors.

Advantage SuperSol 1000+

The SuperSol was designed with the following objectives:

i)    determination of accurate values of the thermodynamic solubility

ii)    focus on low soluble compounds (< 1 g/l)

iii)   low consumption of test material (1 mg)

iv)   simple and fast measurement

 

Equipped with these properties the SuperSol is the ideal choice for solubility determinations from the candidate selection phase up to the pre-clinical phase. The well defined experimental conditions, the standardized operating procedure and the integrated analytics produce results that are reliable and intercomparable (from one lab to another).

Method

A solid sample and solvent (pH buffer etc.) are filled into the thermostatted reaction chamber and the solution is pumped through a flow-through cell inside a closed cycle. The increasing concentration of the dissolving substance is monitored continuously by UV-absorption spectrometry in the flow cell. The solubility equilibrium is reached when no more increase of concentration is observed. Target substance solubility is calculated on the basis of calibration spectra and displayed.

The measurement range can be extended by the exchange of the flow cells. It starts below 1 mg/l and exceeds 1000 mg/l for typical drug compounds.